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Johnson Lab>  Research at a Glance We investigate the structure and function of viruses from a variety of perspectives. We are interested in modes of viral entry, disassembly, assembly, and maturation and in the recognition events associated with each of these processes. By investigating a variety of viruses with genomes stored as single-stranded and double-stranded RNA and as double-stranded DNA, we have developed evolutionary relationships in these functional areas based on structure, genotype, and phenotype. The various virus systems that we study and recent discoveries associated with them are presented here in brief. TSRI Scientific Report 2008 : Johnson Lab (pages 266-267) [pdf] TSRI Scientific Report 2007 : Johnson Lab TSRI Scientific Report 2006 : Johnson Lab TSRI Scientific Report 2005 : Johnson Lab Archaeal Viruses: Sulfolobus Turreted Icosahedral virus Selected Papers Structure of an archaeal virus capsid protein reveals an evolutionary ... The structure of a thermophilic archeal virus shows a dsDNA viral caps... Bromoviridae: Cowpea Chlorotic Mottle Virus (CCMV) Selected Papers Generation and structural analysis of reactive empty particles derived... The role of subunit hinges and molecular "switches" in the control of ... Comparison of the native CCMV virion with in vitro assembled CCMV viri... Structures of the native and swollen forms of cowpea chlorotic mottle ... Comoviridae: Cowpea Mosaic Virus Selected Papers Enhanced Local Symmetry Interactions Globally Stabilize a Mutant Virus... The first crystal structure of a macromolecular assembly under high pr... A virus-based nanoblock with tunable electrostatic properties. New addresses on an addressable virus nanoblock; uniquely reactive Lys... Cowpea mosaic virus: from the presentation of antigenic peptides to th... Icosahedral Virus Particles as Addressable Nanoscale Building Blocks. The refined crystal structure of cowpea mosaic virus at 2.8 A resoluti... Nodaviridae: Flock House Virus (FHV), Pariacoto Virus (PaV), Black Beetle Virus (BBV), Nodamura Virus (NoV) Selected Papers The Combination of Chemical Fixation Procedures with High Pressure Fre... Visualizing Flock House Virus infection in Drosophila cells with corre... Heterologous RNA encapsidated in Pariacoto virus-like particles forms ... Nodavirus coat protein imposes dodecahedral RNA structure independent ... Characterization of virus-like-particles assembled in a recombinant ba... A highly membrane active peptide in Flock House virus: Implications fo... Resolution of Space Group Ambiguity and the Structure Determination of... Ordered duplex RNA controls capsid architecture in an icosahedral anim... Siphoviridae: HK97 Selected Papers An unexpected twist in viral capsid maturation. Virus capsid expansion driven by the capture of mobile surface loops. Capsid conformational sampling in HK97 maturation visualized by X-ray ... Time-resolved molecular dynamics of HK97 virus maturation interpreted ... Evidence that a local refolding event triggers maturation of HK97 bact... Control of crosslinking by quaternary structure changes during bacteri... Crystallization and preliminary crystal analysis of a dsDNA bacterioph... The refined structure of a protein catenane: the HK97 bacteriophage ca... Virus maturation involving large subunit rotations and local refolding... Topologically linked protein rings in the bacteriophage HK97 capsid. Maturation dynamics of a viral capsid: visualization of transitional i... Macromolecular assembly: Chainmail stabilization of a viral capsid. Crystallization and preliminary x-ray analysis of the dsDNA bacterioph... Tetraviridae: Nudaurelia Capensis ω Virus, Providence Virus, Nudaurelia Capensis β Virus Selected Papers Characterization of large conformational changes and autoproteolysis i... Preliminary X-ray Characterization of Authentic Providence Virus and A... Maturation of a tetravirus capsid alters the dynamic properties and cr... Folding and particle assembly are disrupted by single-point mutations ... Correlation of chemical reactivity of Nudaurelia capensis w virus with... Analysis of Rapid, Large-Scale Protein Quaternary Structural Changes: ... Large conformational changes in the maturation of a simple RNA virus, ... The three-dimensional structure of frozen-hydrated Nudaurelia capensis... Totiviridae: L-A Virus Selected Papers The structural basis of recognition and removal of cellular mRNA 7-met... L-A virus at 3.4 Å resolution reveals particle architecture and ... Non-HK97 Bacteriophages Selected Papers Bacteriophage lambda stabilization by auxiliary protein gpD: timing, ... The structure of an infectious P22 virion shows the signal for headful... Highly discriminatory binding of capsid cementing proteins in bacterio... Three-dimensional structure of the bacteriophage P22 tail machine. Preliminary crystallographic analysis of the bacteriophage P22 portal ... VIPERdb (Virus Particle ExploreR) Selected Papers VIPERdb2: an enhanced and web API enabled relational database for ... VIPERdb: a relational database for structural virology. Exploring icosahedral virus structures with VIPER. VIrus Particle ExploreR (VIPER): A website for virus capsid structures...

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